Research results
40 Hz light has been researched by neuroscientist
from world-class institutions It also received awards from
The annual Alzheimer's and Parkinson's (AD/PD) international conference.
In 2016
Nature magazine, volume 540,
pages 230-235 (2016)
The 40Hz therapy for Alzheimer's disease was proposed by the research team of Li-Huei Tsai, a professor in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology (MIT)
The research team published a research paper entitled: "Gamma frequency entrainment attenuates amyloid load and modifies microglia" on "Nature"
"40Hz flickering light" can stimulate Gamma waves in brain of mice with Alzheimer's disease
reduced amyloid beta in the brain, and improved microglial function
In 2021
AD/PD™ Alzheimer's and Parkinson's Disease Conference
A forum for exchanging knowledge on the cutting-edge advancements in the management, research, early identification, pharmaceutical development, and clinical evaluation of Alzheimer's, Parkinson's, and other neurodegenerative diseases.
Announced at the 2021 Alzheimer's and Parkinson's Disease Conference (2021 AD/PD),
its phase 2 clinical results of treating Alzheimer's patients with innovative sound and 40 Hz light stimulation of brain neuron digital therapy
A total of 76 patients with mild to moderate Alzheimer's disease over the age of 50 were included in the study.
During the 6-month treatment period, the patients were randomized to receive visual and auditory stimulation at 40Hz for 1 hour a day at home.
"The rate of decline in memory
and cognitive ability
scores was reduced by 83%,
and brain atrophy was reduced by 61%."
In 2023
Professor Yang, Yuan-Han
Director of the Research Institute Neuroscience Neuroscience Specialist Kaohsiung Medical University have done research
・SH-SY5Y cells are commonly used as an in vitro model of neuronal function and cell differentiation. It has been used to study many fields of neuroscience, including Parkinson's disease, Alzheimer's disease, neurotoxicity, ischemia or amyotrophic lateral sclerosis, and can even be used to study brain cellular and other features of neurogenesis.
・In this experiment, ZUREE composite frequency lamps were used to irradiate SH-SY5Y cells, and compared with cells that were not irradiated, to observe the changes of internal proteins.
・The picture on the left shows the change of protein quantity observed by western blot test. Darker colors indicate higher amounts of protein, and lighter colors indicate lower amounts of protein.
・According to the experimental results, in the cells irradiated with Delta multi-frequency technology, the expression quantity of the two phosphorylated proteins of Tau protein and mTOR protein was significantly reduced, indicating that the light source can inhibit their phosphorylation. Tau protein and mTOR protein, two bad
Experimental images of 40 Hz light
irradiation to SH-SY5Y cells.
From the picture,
the experimental results show that
The side that used 40 Hz light to stimulate Proteins that damage the brain are greatly reduced.
・Tau protein and mTOR protein, two bad proteins, are considered to be the main cause of dementia if they accumulate.
・Aβ40, Aβ42 and tau proteins in cerebrospinal fluid are considered to be potential pathogenesis of dementia Pathological indicators.
・From the experimental results on the left, it can be concluded that
the secretion of Aβ42 in SH-SY5Y cells is inhibited.
・From the experimental results on the left, it can be concluded that
the aggregation of Aβ42 amyloid proteins
can be inhibited in the 40 Hz light source.
・The result of the upper part is to reduce the secretion of amyloid protein. In the pathological mechanism of dementia, the secretion of amyloid protein Aβ42 will increase. After the secretion is increased, these proteins will aggregate, and once aggregated, they will precipitate on the brain As long as pathological changes can be reduced, the two mechanisms of reduction and aggregation are good things for patients.
Comparison pictures
between 40 Hz light exposure
and 40 Hz light exposure
2023 AD/PD international conference paper
2023 AD/PD international conference paper
In 2024
The research received an award
at the 2024 AD/PD conference
ZUREE Brain care light
It has been used on Alzheimer's patients
for a period of time 4 hours/a day, 5 days/a week, for 3 month.
Experiments result ZUREE lamps can
Reduce patient behavior problems
ภาพการนำโคมไฟ ZUREE นำไปใช้กับผู้ป่วย
Reduce symptoms of depression
Reduce the burden on caregivers
